Body Pharm Melanotan II 20mg

The Melanotan II 20 mg pen is a pre-filled multi-dose pen holding 20 mg of peptide in total in a 3 ml cartridge, supplied in Spain for the in vitro and laboratory study of agonist activity at the melanocortin receptors (MC1R–MC5R), and sold exclusively for research purposes and not for human consumption. The dose dial sets the dose directly in milligrams. This page presents the documentation for traceability by batch, the receptor pharmacology in plain language and what the pen format means for dosing.

Last updated: 2026

Melanotan II pen: the essentials

• The multi-dose pen carries 20 mg of peptide in total and its dose dial sets the dose directly in milligrams.
• The research protocol is a loading phase of 200 mcg per day, stepping up to 500 mcg per day, followed by a maintenance phase of 200 mcg twice a week.
• Melanotan II is a non-selective agonist at MC1R, MC3R, MC4R and MC5R; that broad receptor profile sets it apart from selective analogues such as afamelanotide and bremelanotide.
• Every pen is delivered with a certificate of analysis that confirms a purity of ≥ 98% by HPLC, traceability by batch and a check of identity by mass spectrometry.
• Research staff should check the legal status that is in force before they buy, since the classification of peptides can change.
• The dose that is delivered is fixed by the mechanism of the device, not by the technique of the operator.

Who this page is for

Experienced research staff and laboratory procurement officers who are buying a verified 20 mg pen format from Body Pharm Spain, who are already well versed in subcutaneous administration protocols and in cold-chain handling, and who need certainty about the specifications (CoA, storage window, dial steps) before they sign off on the order.

What is Melanotan II 20 mg?

Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH), supplied here as a pre-filled multi-dose pen with 20 mg in total for in vitro and analytical research into the signalling of the melanocortin receptors. It is not a medicine and it is not intended for use in people or in animals.

Compound specification

The reference identifiers that are needed for the procurement and assay documentation:

The acetyl group at the N-terminus and the amide at the C-terminus protect the sequence from cleavage by exopeptidases and prevent enzymatic degradation during storage and handling. The lactam bridge between Asp and Lys forces the molecule to adopt the bioactive β-turn conformation that drives the non-selective agonism at MC1R, MC3R, MC4R and MC5R. Receptor selectivity and the downstream signalling via cAMP are dealt with in the pharmacology section further down.

For the administration parameters in laboratory work, consult our Melanotan II dosing protocol, which forms part of the wider library of peptide guides and dosing protocols.

Melanocortin receptor pharmacology

Melanotan II is a non-selective agonist at MC1R, MC3R, MC4R and MC5R [2][3]. Its action at MC1R increases the synthesis of eumelanin in melanocytes; its action at MC4R explains the effects on appetite and sexual function that were described in the early trials, and is the reason why it was never authorised. The full pharmacology, the trials by Dorr and Wessells and the contrast with afamelanotide are in what is Melanotan II.

The dose dial: why it counts

The Melanotan II pen carries 20 mg of peptide in total in a 3 ml cartridge and its dose dial sets the dose directly in milligrams. That is the point that matters for a protocol: the accuracy of the dose lives in a validated filling line and in the mechanism of the device, not at the laboratory bench of the research staff.

What that means in practice:

• The dose is read off the dial. You set the figure that your protocol calls for and the pen delivers it. The same mark delivers the same mass at every administration, so the dose stops being a source of variance and becomes a controlled variable.
• Long research series without the need to restock. A total content of 20 mg covers a schedule of several weeks from a single device, which matters in subcutaneous dosing studies where restocking halfway through a series introduces a new batch variable.
• A single sealed cartridge. The cartridge remains sealed inside the device for the whole of the series, so there is no need to reopen the primary container between administrations.
• Cold-chain parameters. Store the pen at between 2 and 8 °C and keep it protected from light. While unopened, it keeps for 24 months. Once it has been punctured for the first time, use it within 12 months. If you do not have a refrigerator available, the pen will tolerate up to 30 days at room temperature, with a maximum of 30 °C. Let it come to room temperature before injecting and never freeze it.

Every pen is assembled and filled under an EU laboratory quality system, with batch records that are traceable back to the certificate of analysis (CoA) that is referenced higher up on this page.

For the parameters of subcutaneous administration, consult our Melanotan II dosing protocol or browse the wider library of peptide guides and dosing protocols.

Product specification at a glance

The Melanotan II 20 mg pen is a sealed multi-dose research peptide pen holding 20 mg of MT-II in total, pre-filled, assayed by high-performance liquid chromatography (HPLC) to a purity of ≥ 98% and stored at 2–8 °C. The table below summarises the specifications that a buyer will typically check against a protocol before deciding on the purchase.

For the administration parameters, check the Melanotan II dosing protocol, or the wider library of peptide guides and dosing protocols, against the IFU for your specific batch.

Quality, purity and batch traceability

Every Melanotan II 20 mg pen that we ship is tied to an identified batch number, to an HPLC purity result of ≥ 98% and to a certificate of analysis that is included in the shipment. That unbroken thread from the synthesis lot through to the sealed pen is what we mean by full traceability: research staff can check the batch that is printed on the device against the CoA, and the CoA against our internal quality control register.

Our quality control workflow runs in two stages. First, reversed-phase HPLC quantifies the peptide content and confirms the purity threshold of ≥ 98%. Next, mass spectrometry verifies the identity against the expected parent mass of 1024.2 g/mol for the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂. The assays for residual solvents and for bacterial endotoxins are documented on that same CoA. We apply the assay conventions of EU laboratories for the analysis; that said, buyers should confirm any specific claim of accreditation against the current CoA that is delivered with their order, rather than taking it as read from a product page.

What arrives with each pen

Every pen is filled, checked by weight, sealed and validated for dose before it is dispatched. The shipment includes the CoA for the batch, the IFU and a traceability sheet that links the serial number of the pen to the synthesis lot. Check all of this against the Melanotan II dosing protocol before you use it for the first time.

Shipping, packaging and returns

Orders are shipped with tracking, for a flat shipping charge, to addresses within Spain, with an expected delivery window of 3–5 working days (Body Pharm Spain, 2026). The outer packaging is neutral and unprinted, with no description of the product and no identification of the supplier on the label, so that on the doorstep the parcel looks like any other ordinary tracked delivery.

Returns of unused and unopened items are accepted within 14 days of receipt, provided that the seal on the pen and the outer box are intact. Pens that have been used or opened cannot be returned, because the integrity of the cold chain and the accuracy of the dose cannot be verified again once the device has been handled outside our quality control environment.

Before you open it, check the batch sheet against the Melanotan II dosing protocol, or look for related research material in the wider index of peptide guides and dosing protocols.

Research purposes and regulatory status

Melanotan II is supplied exclusively for in vitro research and as an analytical reference, and it is not an authorised medicine. There is no authorisation of MT-II for use in people, and neither on this page nor in the documentation that accompanies it do we make any therapeutic, cosmetic or health claims about the compound.

Because the classification of peptides can change between publication and purchase, laboratory buyers should check the legal status that is in force before they place an order, above all if their institution requires written regulatory approval for the research materials that it receives [1].

Research staff are expected to work within the ethics, hazardous substances and biosafety frameworks of their own institution. That includes documented risk assessments, secure storage, controlled access to the Melanotan II dosing protocol and to the related peptide guides and dosing protocols, and disposal in line with the procedures of your laboratory for sharps and biological waste.

Notice: This product is sold exclusively for laboratory research and analytical purposes. It is not intended for use in people or in animals, nor for ingestion, nor for administration to living organisms. By purchasing it, you confirm that you are a qualified researcher working within the applicable legislation and the protocols of your institution.

Research dosing protocol resources

For the details of the protocol, turn to the dedicated guide on the Melanotan II dosing protocol and not to this product page. We deliberately keep the titration plans and the guidance on subcutaneous administration out of the listing, so that research staff work from a single, versioned source rather than from a sales page.

The wider library of peptide guides and dosing protocols covers storage handling and protocol templates across the whole of the catalogue, and the skin and pigmentation research category groups MT-II together for comparative work with related compounds that are active at the melanocortin receptors.

All dosing must be carried out strictly within an approved institutional research framework, with documented ethical approval and risk assessment before a pen is put into use.

Frequently Asked Questions

Can I buy Melanotan II 20 mg in Spain?

Melanotan II is not an authorised medicine and is supplied exclusively for laboratory research purposes, not for use in people or in animals. Research staff should check the legal status that is in force before they buy, since the regulation of research peptides can change. Body Pharm sells only to institutional and research buyers who have been verified.

What is the difference between Melanotan I and Melanotan II?

Melanotan I (afamelanotide) is a selective agonist at MC1R, whereas Melanotan II is a non-selective agonist that is active at MC1R, MC3R, MC4R and MC5R. That broader receptor profile is the reason why MT-II is studied in the pathways of pigmentation, appetite and sexual function, while research with MT-I focuses strictly on cutaneous melanogenesis and on photoprotection endpoints.

How is the dose set on the pen?

On the dose dial, directly in milligrams. The multi-dose pen arrives pre-filled and ready for dosing: you set the figure that your protocol calls for and the device delivers that dose. The allocation of dose and frequency is in the Melanotan II dosing protocol.

How should the pen be stored?

Store the pen at between 2 and 8 °C, upright, in its original packaging and keep it protected from light. While unopened, it keeps for 24 months. Once it has been punctured for the first time, use it within 12 months. If you do not have a refrigerator available, the pen will tolerate up to 30 days at room temperature, with a maximum of 30 °C. Let it come to room temperature before injecting and never freeze it. Discard it, regardless of how much content remains, if the solution shows discolouration, particles or cloudiness.

What documentation comes with each batch?

Every batch is delivered with a certificate of analysis that refers back to the batch number printed on the pen, giving the HPLC purity, the identity of the peptide and the results of the screening for contaminants. Research staff can request the CoA before they order and check it against the unit that is delivered. There is further methodological guidance in the library of peptide guides and dosing protocols.

Next steps

Before you order, check the legal status that is in force and cross-check the Melanotan II dosing protocol against the ethics and hazardous substances frameworks of your institution. Once you have written approval in hand, request a certificate of analysis for the intended batch and confirm that it meets the requirements of your protocol. For questions that are specific to a batch before checkout, contact Body Pharm directly.

Sources

1. EMA, list of authorised medicines for human use in the EU (EPAR). ema.europa.eu — accessed October 2026 for the regulatory status of the compound.
2. Wikberg JE, et al. New aspects on the melanocortins and their receptors. Pharmacol Res. 2000. pubmed.ncbi.nlm.nih.gov/11023702
3. Cone RD. Anatomy and regulation of the central melanocortin system. Nat Neurosci. 2005. pubmed.ncbi.nlm.nih.gov/15856065